The CSP team has just published an article in ACS Applied Materials & Interfaces reporting fluorescent pH-sensitive dextran conjugates that enable accurate ratiometric measurement of cerebral blood pH in vivo and in situ.
In this work, the CSP group, in collaboration with the team of Serge Charpak (Institut de la vision, Paris), developed a PEGylated version of the H-Ruby fluorophore, overcoming aggregation-caused quenching and improving both fluorescence brightness and two-photon absorption properties. Applied to live mouse brain imaging, this approach allowed precise monitoring of vascular acidosis during hypercapnia.
