Jean-Serge Remy

Short biosketch CV

Jean-Serge Remy is Research director at the CNRS.
Some career elements:

PhD in Pharmaco-Chemistry in the “Genetic Chemistry” team of Dr. Jean-Paul Behr (1990-1994), on gene transfer using cationic lipids.
Postdoctoral position at the University of California San Francisco (UCSF) in the laboratory of Prof. Francis D. Szoka Jr. (1995).
CNRS researcher since 1995.
Director of the “Genetic Chemistry” team (2006-2012).
Co-founder and member of the LabEx Medalis (2012-2017).
Deputy director of UMR 7199 (CAMB; 2012), then Director (2013-2023).
Member of the icFRC steering committee (2013-2023).
Deputy director of the Doctoral School of Chemistry ED 222 (2014-2016), then Director (2017-2019).

73 publications disponibles

Articles scientifiques
Parties d'ouvrages
Productions de vulgarisation

Articles scientifiques

Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy, Frontiers in Chemistry | 2020
Co-auteur(s) : Boris Gaillard - Francoise Pons-lebeau - Luc Lebeau
Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs, Pharmaceutical Research | 2020
Co-auteur(s) : Boris Gaillard - Francoise Pons-lebeau - Luc Lebeau
Design and evaluation of ionizable peptide amphiphiles for siRNA delivery, International Journal of Pharmaceutics | 2019
Co-auteur(s) : Patrick Neuberg - Alain Wagner - Antoine Kichler
Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy, Chemistry – A European Journal | 2019
Co-auteur(s) : Boris Gaillard - Cendrine Seguin - Francoise Pons - Luc Lebeau
Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids, Molecular Therapy - Nucleic Acids | 2018
Co-auteur(s) : Marc Nothisen - Phanélie Perche-Létuvée - Jean-Paul Behr - Mitsuharu Kotera
Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing, RSC Advances | 2018
Co-auteur(s) : Manon Ripoll - Marie Pierdant - Patrick Neuberg - Dominique Bagnard - Alain Wagner - Antoine Kichler
Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery, Nanoscale | 2018
Co-auteur(s) : Patrick Neuberg - Imene Hamaidi - Sabrina Danilin - Manon Ripoll - Veronique Lindner - Marc Nothisen - Alain Wagner - Antoine Kichler - Thierry Massfelder
From solution to in-cell study of the chemical reactivity of acid sensitive functional groups, Organic and Biomolecular Chemistry | 2016
Co-auteur(s) : Sylvain Jacques - Geoffray Leriche - Michel Mosser - Marc Nothisen - Christian Muller - Alain Wagner
From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release, Organic and Biomolecular Chemistry | 2016
Co-auteur(s) : Sylvain A. Jacques - Geoffray Leriche - Michel Mosser - Marc Nothisen - Christian Muller - Alain Wagner
Preparation of poly(ethylene imine) derivatives with precisely controlled molecular weight, European Polymer Journal | 2016
Co-auteur(s) : Matthieu Landa - Mitsuharu Kotera - Nezha Badi
Structure Tuning of Cationic Oligospermine–siRNA Conjugates for Carrier-Free Gene Silencing, Molecular Pharmaceutics | 2016
Co-auteur(s) : Marc Nothisen - Jérémy Bagilet - Jean-Paul Behr - Mitsuharu Kotera
Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection, Nature Chemistry | 2016
Co-auteur(s) : Antonio Munoz - David Sigwalt - Beatriz Illescas - Joanna Luczkowiak - Laura Rodriguez-Perez - Iwona Nierengarten - Michel Holler - Kevin Buffet - Stéphane Vincent - Javier Rojo - Rafael Delgado - Jean-françois Nierengarten - Nazario Martin
pH-Responsive Nanometric Polydiacetylenic Micelles Allow for Efficient Intracellular siRNA Delivery, ACS Applied Materials and Interfaces | 2016
Co-auteur(s) : Manon Ripoll - Patrick Neuberg - Antoine Kichler - Nassera Tounsi - Alain Wagner
Mannoside Glycolipid Conjugates Display Anti-inflammatory Activity by Inhibition of Toll-like Receptor-4 Mediated Cell Activation, ACS Chemical Biology | 2015
Co-auteur(s) : Vincent Flacher - Patrick Neuberg - Floriane Point - François Daubeuf - Quentin Muller - David Sigwalt - Jean-Daniel Fauny - Nelly Frossard - Alain Wagner - Christopher G Mueller - Evelyne Schaeffer
Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties, Chemical Communications | 2015
Co-auteur(s) : Patrick Neuberg - Aurelia Perino - Emmanuelle Morin-Picardat - Nicolas Anton - Zeinab Darwich - Denis Weltin - Yves Mely - Andrey Klymchenko - Alain Wagner
Spiro Diorthoester (SpiDo), a Human Plasma Stable Acid-Sensitive Cleavable Linker for Lysosomal Release, Bioconjugate Chemistry | 2015
Co-auteur(s) : Geoffray Leriche - Marc Nothisen - Nadege Baumlin - Christian Muller - Dominique Bagnard - Sylvain Jacques - Alain Wagner
Bio-specific and bio-orthogonal chemistries to switch-off the quencher of a FRET-based fluorescent probe: application to living-cell biothiol imaging, Chemical Communications | 2014
Co-auteur(s) : Coraline Egloff - Sylvain Jacques - Marc Nothisen - D Weltin - C Calligaro - Michel Mosser - Alain Wagner
Selective Irreversible Chemical Tagging of Cysteine with 3-Arylpropiolonitriles, Bioconjugate Chemistry | 2014
Co-auteur(s) : Oleksandr Koniev - Geoffray Leriche - Marc Nothisen - Jean Marc Strub - Christine Schaeffer-Reiss - Alain Van Dorsselaer - Rachid Baati - Alain Wagner
Cell-penetrating cationic siRNA and lipophilic derivatives efficient at nanomolar concentrations in the presence of serum and albumin, Journal of Controlled Release | 2013
Co-auteur(s) : Phanelie Perche - Marc Nothisen - Jeremy Bagilet - Jean-Paul Behr - Mitsuharu Kotera
Dynamic Micelles of Mannoside Glycolipids are more Efficient than Polymers for Inhibiting HIV-1 trans-Infection, Bioconjugate Chemistry | 2013
Co-auteur(s) : Evelyne Schaeffer - Laure Dehuyser - David Sigwalt - Vincent Flacher - Serena Bernacchi - Olivier Chaloin - Christopher G Mueller - Rachid Baati - Alain Wagner
Dynamic Micelles of Mannoside Glycolipids are more Efficient than Polymers for Inhibiting HIV-1 trans-infection., Bioconjugate Chemistry | 2013
Co-auteur(s) : Evelyne Schaeffer - Laure Dehuyser - David Sigwalt - Vincent Flacher - Serena Bernacchi - Olivier Chaloin - Christopher G Mueller - Rachid Baati - Alain Wagner
Polycationic Pillar 5 arene Derivatives: Interaction with DNA and Biological Applications, Chemistry - A European Journal | 2013
Co-auteur(s) : Iwona Nierengarten - Marc Nothisen - David Sigwalt - Thomas Biellmann - Michel Holler - Jean-Francois Nierengarten
Cationic Polydiacetylene Micelles for Gene Delivery, Bioconjugate Chemistry | 2011
Co-auteur(s) : Emmanuelle Morin - Marc Nothisen - Alain Wagner
Gene delivery with polycationic fullerene hexakis-adducts, Chemical Communications | 2011
Co-auteur(s) : David Sigwalt - Michel Holler - Julien Iehl - Jean-françois Nierengarten - Marc Nothisen - Emmanuelle Morin
MMT, Npeoc-protected spermine, a valuable synthon for the solid phase synthesis of oligonucleotide oligospermine conjugates via guanidine linkers, Bioorganic and Medicinal Chemistry | 2011
Co-auteur(s) : Phanelie Perche - Mitsuharu Kotera
Adenovirus-derived vectors for prostate cancer gene therapy., Human Gene Therapy | 2010
Co-auteur(s) : J de Vrij - R Willemsen - L Lindholm - R Hoeben - G Consortium - C Bangma - C Barber - J Behr - S Briggs - R Carlisle - W Cheng - I Dautzenberg - C de Ridder - H Dzojic - P Erbacher - M Essand - K Fisher - A Frazier - L Georgopoulos - I Jennings - S Kochanek - D Koppers-Lalic - R Kraaij - F Kreppel - M Magnusson - N Maitland - P Neuberg - R Nugent - M Ogris - M Scaife - E Schenk-Braat - E Schooten - L Seymour - M Slade - P Szyjanowicz - T Totterman - T Uil - K Ulbrich - L van der Weel - W van Weerden - E Wagner - G Zuber
Fine-Tuning the Morphology of Self-Assembled Nanostructures of Propargyl Ammonium-Based Amphiphiles, The Journal of Physical Chemistry B | 2010
Co-auteur(s) : Emmanuelle Morin - Jean-Michel Guenet - David D. Díaz - Alain Wagner
Proton Sponge Trick for pH-Sensitive Disassembly of Polyethylenimine-Based siRNA Delivery Systems, Bioconjugate Chemistry | 2010
Co-auteur(s) : Gaelle Creusat - Anne-Sophie Rinaldi - Etienne Weiss - Rkia Elbaghdadi - Rita Mulherkar - Guy Zuber
Tailoring drug release profile of low-molecular-weight hydrogels by supramolecular co-assembly and thiol-ene orthogonal coupling, Journal of Materials Chemistry | 2010
Co-auteur(s) : David Diaz - Emmanuelle Morin - Eva Schoen - Ghyslain Budin - Alain Wagner
Cationic siRNAs Provide Carrier-Free Gene Silencing in Animal Cells, Journal of the American Chemical Society | 2009
Co-auteur(s) : Marc Nothisen - Mitsuharu Kotera - Emilie Voirin - Jean-Paul Behr
Zip Nucleic Acids: new high affinity oligonucleotides as potent primers for PCR and reverse transcription, Nucleic Acids Research | 2009
Co-auteur(s) : Valérie Moreau - Emilie Voirin - Clément Paris - Mitsuharu Kotera - Marc Nothisen - Jean-Paul Behr - Patrick Erbacher - Nathalie Lenne-Samuel
Oligonucleotide−Oligospermine Conjugates (Zip Nucleic Acids): A Convenient Means of Finely Tuning Hybridization Temperatures, Journal of the American Chemical Society | 2008
Co-auteur(s) : Régis Noir - Mitsuharu Kotera - Bénédicte Pons - Jean-Paul Behr
A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin, The Journal of Gene Medicine | 2004
Co-auteur(s) : Idit Kopatz - Jean-Paul Behr
Effective polyethylenimine-mediated gene transfer into human endothelial cells, The Journal of Gene Medicine | 2004
Co-auteur(s) : Violeta Zaric - Denis Weltin - Patrick Erbacher - Jean-Paul Behr - Dominique Stephan
Genuine DNA/polyethylenimine (PEI) Complexes Improve Transfection Properties and Cell Survival, Journal of Drug Targeting | 2004
Co-auteur(s) : Patrick Erbacher - Thierry Bettinger - Emmanuel Brion - Jean-Luc Coll - Christian Plank - Jean-Paul Behr
The Magnetofection Method: Using Magnetic Force to Enhance Gene Delivery, Biological Chemistry | 2003
Co-auteur(s) : Christian Plank - Ulrike Schillinger - Franz Scherer - Christian Bergemann - Florian Krötz - Marina Anton - Jim Lausier - Joseph Rosenecker
Development of plasmid and oligonucleotide nanometric particles, Gene Therapy | 2002
Co-auteur(s) : Emmanuel Dauty - Jean-Paul Behr
Intracellular Delivery of Nanometric DNA Particles via the Folate Receptor, Bioconjugate Chemistry | 2002
Co-auteur(s) : Emmanuel Dauty - Guy Zuber - Jean-Paul Behr
Intracellular delivery of nanometric DNA particles via the folate receptor, Bioconjugate Chemistry | 2002
Co-auteur(s) : Emmanuel Dauty - Guy Zuber - Jean-Paul Behr
Dimerizable Cationic Detergents with a Low cmc Condense Plasmid DNA into Nanometric Particles and Transfect Cells in Culture, Journal of the American Chemical Society | 2001
Co-auteur(s) : Emmanuel Dauty - Thomas Blessing - Jean-Paul Behr
Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver, Gene Therapy | 2001
Co-auteur(s) : M Robaczewska - S Guerret - I Chemin - W-B Offensperger - M Chevallier - Jean-Paul Behr - A J Podhajska - H E Blum - C Trepo - L Cova
Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity, Gene Therapy | 2001
Co-auteur(s) : K Aoki - S Furuhata - K Hatanaka - M Maeda - Jean-Paul Behr - M Terada - T Yoshida
Dimerizable Detergents as Gene Transfer Vectors, Journal of Liposome Research | 2000
Co-auteur(s) : Thomas Blessing - Emmanuel Dauty - Jean-Paul Behr
Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery, Gene Therapy | 2000
Co-auteur(s) : D Finsinger - P Erbacher - C Koch - C Plank
Systemic linear polyethylenimine (L‐PEI)‐mediated gene delivery in the mouse, Journal of Gene Medicine | 2000
Co-auteur(s) : Shao-Min Zou - Patrick Erbacher - Jean-Paul Behr
The p21 cip1/waf1 cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells, Cancer Letters | 2000
Co-auteur(s) : H. Lincet - L. Poulain - E. Deslandes - C. Duigou - P. Gauduchon - C. Staedel
Controlled Template-Assisted Assembly of Plasmid DNA into Nanometric Particles with High DNA Concentration, Bioconjugate Chemistry | 1999
Co-auteur(s) : Ming Ouyang - Francis C. Szoka
Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway, Gene Therapy | 1999
Co-auteur(s) : Patrick Erbacher - Jean-Paul Behr
Polyethylenimine but Not Cationic Lipid Improves Antisense Activity of 3′-Capped Phosphodiester Oligonucleotides, Antisense and Nucleic Acid Drug Development | 1999
Co-auteur(s) : Sonia Dheur - Nathalie Dias - Arthur Van Aerschot - Piet Herdewijn - Thierry Bettinger - Claude Hélène - E. Tula Saison-Behmoaras
Size Reduction of Galactosylated PEI/DNA Complexes Improves Lectin-Mediated Gene Transfer into Hepatocytes, Bioconjugate Chemistry | 1999
Co-auteur(s) : Thierry Bettinger - Patrick Erbacher
Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody‐derivatized polyethylenimines (PEI), Journal of Gene Medicine | 1999
Co-auteur(s) : Patrick Erbacher - Thierry Bettinger - Pascale Belguise-Valladier - Shaomin Zou - Jean-Luc Coll - Jean-Paul Behr
Chitosan-Based Vector/DNA Complexes for Gene Delivery: Biophysical Characteristics and Transfection Ability, Pharmaceutical Research | 1998
Co-auteur(s) : Patrick Erbacher - Shaomin Zou - Thierry Bettinger - Anne‐Marie Steffan
Convenient Polymer-Supported Synthetic Route to Heterobifunctional Polyethylene Glycols, Bioconjugate Chemistry | 1998
Co-auteur(s) : Thierry Bettinger - Patrick Erbacher - Jean-Paul Behr
Gene transfer with lipospermines and polyethylenimines, Advanced Drug Delivery Reviews | 1998
Co-auteur(s) : Bassima Abdallah - Maria Antonietta Zanta - Otmane Boussif - Jean-Paul Behr - Barbara Demeneix
Monomolecular collapse of plasmid DNA into stable virus-like particles, Proceedings of the National Academy of Sciences | 1998
Co-auteur(s) : Thomas Blessing - Jean-Paul Behr
Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells, Journal of Biological Chemistry | 1998
Co-auteur(s) : Hélène Pollard - Gildas Loussouarn - Sophie Demolombe - Jean-Paul Behr - Denis Escande
Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system, Gene Therapy | 1998
Co-auteur(s) : Daniel Goula - Patrick Erbacher - M Wasowicz - G Levi - B Abdallah - BA Demeneix
Template Oligomerization of DNA-Bound Cations Produces Calibrated Nanometric Particles, Journal of the American Chemical Society | 1998
Co-auteur(s) : Thomas Blessing - Jean-Paul Behr
Delivery of Polynucleotides with Polyamine Lipids and Polymers, Nucleosides and Nucleotides | 1997
Co-auteur(s) : B. A. Demeneix - Otmane Boussif - Maria Antonietta Zanta - Jean-Paul Behr
Lipospermine-mediated gene transfer technique into murine cultured cortical cells, Journal of Neuroscience Methods | 1997
Co-auteur(s) : Brigitte Sola - Cathy Staedel - Amina Bahr - Jean-paul Behr
Gene Transfer with Multivalent Synthetic Vectors, Journal of Liposome Research | 1996
Co-auteur(s) : Jean-Paul Behr
Efficient Gene Delivery with Neutral Complexes of Lipospermine and Thiol-Reactive Phospholipids, Biochemical and Biophysical Research Communications | 1995
Co-auteur(s) : Antoine Kichler - Otmane Boussif - Benoît Frisch - Christophe Boeckler - Jean-Paul Behr - Francis Schuber
Synthesis and Evaluation as a Gene Transfer Agent of a 1,2-Dimyristoyl-glycero-3-pentalysine Salt, Chemistry Letters | 1995
Co-auteur(s) : Jean-Marc Weibel - Antoine Kichler - Christian Gaiddon - Jean-Philippe Loeffler - Guy Duportail - Denis Heissler
Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses., Proceedings of the National Academy of Sciences | 1995
Co-auteur(s) : Antoine Kichler - V. Mordvinov - Francis Schuber - Jean-Paul Behr
Gene Transfer with a Series of Lipophilic DNA-Binding Molecules, Bioconjugate Chemistry | 1994
Co-auteur(s) : Claude Sirlin - Pierre Vierling - Jean-Paul Behr
High-Efficiency Transfection of Primary Human Keratinocytes with Positively Charged Lipopolyamine: DNA Complexes, Journal of Investigative Dermatology | 1994
Co-auteur(s) : Cathy Staedel - Zhongxue Hua - Thomas R Broker - Louise T Chow - Jean-Paul Behr
Gene Transfer Optimization with Lipospermine-Coated DNA, DNA and Cell Biology | 1993
Co-auteur(s) : Fabrice Barthel - Jean-philippe Loeffler - Jean-Paul Behr

Parties d'ouvrages

Cationic Photopolymerized Polydiacetylenic (PDA) Micelles for siRNA Delivery, Nanotechnology for Nucleic Acid Delivery | 2019
Co-auteur(s) : Manon Ripoll - Patrick Neuberg - Antoine Kichler
Virus-like nanoparticles for Gene Therapy | 2006
Co-auteur(s) : Guy Zuber - D. Dalkara
Molecular Vectors for Gene Delivery to Cancer Cells, Nucleic Acid Therapeutics in Cancer | 2004
Co-auteur(s) : Guy Zuber - Patrick Erbacher - Pascale Belguise - Jean-Paul Behr
Taking lipospermines and polyethylenimine from in vitro to in vivo, Self-assembling complexes for gene delivery: From laboratory to clinical trial | 1998
Co-auteur(s) : Daniel Goula - Anne-Marie Steffan - Maria Antonietta Zanta - Otmane Boussif - Jean-Paul Behr - Barbara Demeneix
Gene transfer with cationic amphiphiles, Liposomes in basic research and industry | 1995
Co-auteur(s) : Claude Sirlin - Jean-Paul Behr