Unistra publications
59 publications disponibles
Articles scientifiques
- Seeing in the Future – a Perspective on Combining Light with Chemical Biology Approaches to Treat Retinal Pathologies, ChemMedChem | 2025
Co-auteur(s) : Alexandre Specht - Maxime Klimezak - Sidney Cambridge - In Vivo Optogenetic Manipulation of Transgene Expression in Retinal Neurovasculature, JACS Au | 2024
Co-auteur(s) : Eric Brandhorst - Liang Xu - Maxime Klimezak - Bastien Goegan - Huixiao Hong - Hans-Peter Hammes - Alexandre Specht - Sidney Cambridge - Triplet‐Triplet Annihilation Upconversion‐Based Photolysis: Applications in Photopharmacology, Advanced Healthcare Materials | 2024
Co-auteur(s) : Maxime Klimezak - Juliane Chaud - Anaïs Brion - Frédéric Bolze - Benoît Frisch - Béatrice Heurtault - Antoine Kichler - Alexandre Specht - Photoactivatable Liposomes for Blue to Deep Red Light-Activated Surface Drug Release: Application to Controlled Delivery of the Antitumoral Drug Melphalan, Bioconjugate Chemistry | 2023
Co-auteur(s) : Anaïs Brion - Juliane Chaud - Maxime Klimezak - Frédéric Bolze - Laura Ohlmann - Jérémie Leonard - Stefan Chassaing - Benoît Frisch - Antoine Kichler - Béatrice Heurtault - Alexandre Specht - Synthesis and Photochemical Properties of Fluorescent Metabolites Generated from Fluorinated Benzoylmenadiones in Living Cells, The Journal of Organic Chemistry | 2023
Co-auteur(s) : Nathan Trometer - Bogdan Cichocki - Quentin Chevalier - Jérémy Pécourneau - Jean-Marc Strub - Andrea Hemmerlin - Alexandre Specht - Elisabeth Davioud-Charvet - Mourad Elhabiri - Towards a Light‐mediated Gene Therapy for the Eye using Caged Ethinylestradiol and the Inducible Cre/lox System, Angewandte Chemie International Edition | 2023
Co-auteur(s) : Zoe Kiy - Juliane Chaud - Liang Xu - Eric Brandhorst - Tschackad Kamali - Carolyn Vargas - Sandro Keller - Huixiao Hong - Alexandre Specht - Sidney Cambridge - Red Light‐Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin‐Based Prodrug, Advanced Healthcare Materials | 2022
Co-auteur(s) : Anaïs Brion - Juliane Chaud - Jérémie Léonard - Frédéric Bolze - Stefan Chassaing - Benoît Frisch - Béatrice Heurtault - Antoine Kichler - Alexandre Specht - Wavelength-Dependent, Orthogonal Photoregulation of DNA Liberation for Logic Operations, ACS Applied Materials & Interfaces | 2022
Co-auteur(s) : Ling Sum Liu - Hoi Man Leung - Clement Morville - Hoi Ching Chu - Jing Yi Tee - Alexandre Specht - Frédéric Bolze - Pik Kwan Lo - Photolytical reactions for light induced biological effectors release: on the road to the phototherapeutic window, Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2021
Co-auteur(s) : Clement Morville - Juliane Chaud - Frederic Bolze - Alexandre Specht - Two-Photon Sensitive Coumarinyl Photoremovable Protecting Groups with Rigid Electron-Rich Cycles Obtained by Domino Reactions Initiated by a 5- exo -Dig Cyclocarbopalladation, Organic Letters | 2021
Co-auteur(s) : Juliane Chaud - Clement Morville - Frederic Bolze - Delphine Garnier - Stephane Chassaing - Gaelle Blond - Alexandre Specht - Development and characterization of layer-by-layer coated liposomes with poly(L-lysine) and poly(L-glutamic acid) to increase their resistance in biological media, International Journal of Pharmaceutics | 2020
Co-auteur(s) : Florence Hermal - Benoit Frisch - Alexandre Specht - Line Bourel-Bonnet - Béatrice Heurtault - Monitoring of uncaging processes by designing photolytical reactions, Photochemical & Photobiological Sciences | 2020
Co-auteur(s) : Elie Abou Nakad - Juliane Chaud - Clement Morville - Frederic Bolze - Alexandre Specht - Synthesis and Characterization of Photoactivatable Doxycycline Analogues Bearing Two-Photon-Sensitive Photoremovable Groups Suitable for Light-Induced Gene Expression, ChemBioChem | 2018
Co-auteur(s) : Bastien Goegan - Firat Terzi - Frederic Bolze - Sidney Cambridge - Alexandre Specht - o -Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties, Organic and Biomolecular Chemistry | 2018
Co-auteur(s) : Elie Abou Nakad - Frédéric Bolze - Alexandre Specht - On the permeation of large organic cations through the pore of ATP-gated P2X receptors, Proceedings of the National Academy of Sciences | 2017
Co-auteur(s) : Mahboubi Harkat - Laurie Peverini - Adrien Cerdan - Kate Dunning - Juline Beudez - Adeline Martz - Nicolas Calimet - Alexandre Specht - Marco Cecchini - Thierry Chataigneau - Thomas Grutter - Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel, eLife | 2016
Co-auteur(s) : Chloé Habermacher - Adeline Martz - Nicolas Calimet - Damien Lemoine - Laurie Peverini - Alexandre Specht - Marco Cecchini - Thomas Grutter - Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging, Angewandte Chemie | 2016
Co-auteur(s) : Manuela A. H. Fichte - Xenia M. M. Weyel - Stephan Junek - Florian Schäfer - Cyril Herbivo - Maurice Goeldner - Alexandre Specht - Josef Wachtveitl - Alexander Heckel - Two-photon sensitive photolabile protecting groups: From molecular engineering to nanostructuration, Molecular Crystals and Liquid Crystals | 2016
Co-auteur(s) : Sébastien Piant - Alexandre Specht - Boris Zemelman - Attila Losonczy - Frédéric Bolze - Two-photon uncaging, from neuroscience to materials, Optical Materials Express | 2016
Co-auteur(s) : Sébastien Piant - Frederic Bolze - Alexandre Specht - A Polyurethane-Based Positive Photoresist, Macromolecular Rapid Communications | 2014
Co-auteur(s) : Luis Garcia-Fernandez - Alexandre Specht - Aranzazu del Campo - Dual Photosensitive Polymers with Wavelength-Selective Photoresponse, Advanced Materials | 2014
Co-auteur(s) : Luis Garcia-Fernandez - Cyril Herbivo - Veronica Arranz - David Warther - Loic Donato - Alexandre Specht - Aranzazu del Campo - Characterization of one- and two-photon photochemical uncaging efficiency, Methods in Molecular Biology | 2013
Co-auteur(s) : Alexandre Specht - Frédéric Bolze - Jean-François Nicoud - Maurice Goeldner - Optical control of an ion channel gate, Proceedings of the National Academy of Sciences of the United States of America | 2013
Co-auteur(s) : Damien Lemoine - Chloe Habermacher - Adeline Martz - Pierre-Francois Mery - Nathalie Bouquier - Fanny Diverchy - Antoine Taly - Francois Rassendren - Alexandre Specht - Thomas Grutter - Synthesis and Characterization of Cell-Permeable Caged Phosphates that Can Be Photolyzed by Visible Light or 800 nm Two-Photon Photolysis, ChemBioChem | 2013
Co-auteur(s) : Cyril Herbivo - Ziad Omran - Julia Revol - Helene Javot - Alexandre Specht - Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor, Channels | 2012
Co-auteur(s) : Ruotian Jiang - Antoine Taly - Damien Lemoine - Adeline Martz - Alexandre Specht - Thomas Grutter - Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition, Chemical Reviews | 2012
Co-auteur(s) : Damien Lemoine - Ruotian Jiang - Antoine Taly - Thierry Chataigneau - Alexandre Specht - Thomas Grutter - The donor-acceptor biphenyl platform: A versatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups, Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences | 2012
Co-auteur(s) : Alexandre Specht - Frédéric Bolze - Loic Donato - Cyril Herbivo - Sébastien Charon - David Warther - Sylvestre Gug - Jean-francois Nicoud - Maurice Goeldner - The donor-acceptor biphenyl platform: Aversatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups, Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences | 2012
Co-auteur(s) : Alexandre Specht - Frédéric Bolze - Loic Donato - Cyril Herbivo - Sebastien Charon - David Warther - Sylvestre Gug - Jean-François Nicoud - Maurice Goeldner - Two-photon uncaging: The chemist point of view, Optical Materials | 2012
Co-auteur(s) : Frederic Bolze - Jean-francois Nicoud - Cyril Bourgogne - S Gug - X Sun - Maurice Goeldner - Alexandre Specht - L Donato - D Warther - G Turi - A Losonczy - Water-Soluble, Donor-Acceptor Biphenyl Derivatives in the 2-(o-Nitrophenyl)propyl Series: Highly Efficient Two-Photon Uncaging of the Neurotransmitter gamma-Aminobutyric Acid at lambda=800 nm, Angewandte Chemie International Edition | 2012
Co-auteur(s) : Loic Donato - Alexandre Mourot - Christopher Davenport - Cyril Herbivo - David Warther - Jeremie Leonard - Frederic Bolze - Jean-francois Nicoud - Richard Kramer - Maurice Goeldner - Alexandre Specht - Agonist trapped in ATP-binding sites of the P2X2 receptor, Proceedings of the National Academy of Sciences of the United States of America | 2011
Co-auteur(s) : Ruotian Jiang - Damien Lemoine - Adeline Martz - Antoine Taly - Sophie Gonin - Lia de Carvalho - Alexandre Specht - Thomas Grutter - Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA(A) receptors in vitro, British Journal of Pharmacology | 2011
Co-auteur(s) : Ruotian Jiang - Akiko Miyamoto - Adeline Martz - Alexandre Specht - Hitoshi Ishibashi - Marie Kueny-Stotz - Stefan Chassaing - Raymond Brouillard - Lia de Carvalho - Maurice Goeldner - Junichi Nabekura - Mogens Nielsen - Thomas Grutter - Small photoactivatable molecules for controlled fluorescence activation in living cells, Bioorganic and Medicinal Chemistry | 2011
Co-auteur(s) : David Puliti - David Warther - Clelia Orange - Alexandre Specht - Maurice Goeldner - Time-Resolved WAXS Reveals Accelerated Conformational Changes in Iodoretinal-Substituted Proteorhodopsin, Biophysical Journal | 2011
Co-auteur(s) : Erik Malmerberg - Ziad Omran - Jochen Hub - Xuewen Li - Gergely Katona - Sebastian Westenhoff - Linda Johansson - Magnus Andersson - Marco Cammarata - Michael Wulff - David van der Spoel - Jan Davidsson - Alexandre Specht - Richard Neutze - Live-Cell One- and Two-Photon Uncaging of a Far-Red Emitting Acridinone Fluorophore, Journal of the American Chemical Society | 2010
Co-auteur(s) : David Warther - Frédéric Bolze - Jérémie Leonard - Sylvestre Gug - Alexandre Specht - David Puliti - Xiao-Hua Sun - Pascal Kessler - Yves Lutz - Jean-Luc Vonesch - Barbara Winsor - Jean-francois Nicoud - Maurice Goeldner - Two-photon uncaging: New prospects in neuroscience and cellular biology, Bioorganic and Medicinal Chemistry | 2010
Co-auteur(s) : David Warther - Sylvestre Gug - Alexandre Specht - Frédéric Bolze - Jean-francois Nicoud - Alexandre Mourot - Maurice Goeldner - Complexing photolabile cholinergic ligands with synthetic and biological receptors: a dynamic survey, Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2009
Co-auteur(s) : Alexandre Specht - S. Loudwig - Ling Peng - Maurice Goeldner - Photochemical tools to study dynamic biological processes, HFSP Journal | 2009
Co-auteur(s) : Alexandre Specht - Frédéric Bolze - Ziad Omran - Jean-francois Nicoud - Maurice Goeldner - Short-length dimethoxynitrophenyl photo-cleavable crosslinkers, synthesis and photolysis, Journal of Photochemistry and Photobiology A: Chemistry | 2009
Co-auteur(s) : Ziad Omran - Alexandre Specht - Synthesis and photochemical properties of photo-cleavable crosslinkers, Tetrahedron Letters | 2009
Co-auteur(s) : Ziad Omran - Alexandre Specht - Comparative models of P2X2 receptor support inter-subunit ATP-binding sites, Biochemical and Biophysical Research Communications | 2008
Co-auteur(s) : Guillaume Guerlet - Antoine Taly - Lia Prado De Carvalho - Adeline Martz - Ruotian Jiang - Alexandre Specht - Nicolas Le Novère - Thomas Grutter - Molecular Engineering of Photoremovable Protecting Groups for Two‐Photon Uncaging, Angewandte Chemie International Edition | 2008
Co-auteur(s) : Sylvestre Gug - Frédéric Bolze - Alexandre Specht - Cyril Bourgogne - Maurice Goeldner - Jean-Francois Nicoud - Photolabile Glutamate Protecting Group with High One- and Two-Photon Uncaging Efficiencies, ChemBioChem | 2008
Co-auteur(s) : Sylvestre Gug - Sébastien Charon - Alexandre Specht - Karine Alarcon - David Ogden - Burkhard Zietz - Jeremie Leonard - Stefan Haacke - Frederic Bolze - Jean-francois Nicoud - Maurice Goeldner - Phototriggering of Cell Adhesion by Caged Cyclic RGD Peptides, Angewandte Chemie International Edition | 2008
Co-auteur(s) : Svea Petersen - José María Alonso - Alexandre Specht - Portia Duodu - Maurice Goeldner - Aranzazu del Campo - Phototriggering of Cell Adhesion by Caged Cyclic RGD Peptides, Angewandte Chemie | 2008
Co-auteur(s) : Svea Petersen - José María Alonso - Alexandre Specht - Portia Duodu - Maurice Goeldner - Aranzazu del Campo - Synthesis and photochemical properties of a light-activated fluorophore to label His-tagged proteins, Chemical Communications | 2008
Co-auteur(s) : Clélia Orange - Alexandre Specht - David Puliti - Elias Sakr - Toshiaki Furuta - Barbara Winsor - Maurice Goeldner - The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na + /Sugar Symport, Science | 2008
Co-auteur(s) : Salem Faham - Akira Watanabe - Gabriel Mercado Besserer - Duilio Cascio - Alexandre Specht - Bruce A. Hirayama - Ernest M. Wright - Jeff Abramson - Use of a `caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography, Acta Crystallographica Section D Biological Crystallography | 2007
Co-auteur(s) : Jacques-Philippe Colletier - Antoine Royant - Alexandre Specht - Benoît Sanson - Florian Nachon - Patrick Masson - Giuseppe Zaccai - Joel L. Sussman - Maurice Goeldner - Israel Silman - Dominique Bourgeois - Martin Weik - New Photoremovable Protecting Groups for Carboxylic Acids with High Photolytic Efficiencies at Near‐UV Irradiation. Application to the Photocontrolled Release of L ‐Glutamate, ChemBioChem | 2006
Co-auteur(s) : Alexandre Specht - Jean‐Sébastien Thomann - Karine Alarcon - Weerawut Wittayanan - David Ogden - Toshiaki Furuta - Yuji Kurakawa - Maurice Goeldner - para ‐Sulfonated Calixarenes Used as Synthetic Receptors for Complexing Photolabile Cholinergic Ligand, Helvetica Chimica Acta | 2005
Co-auteur(s) : Alexandre Specht - Fabio Ziarelli - Philippe Bernard - Maurice Goeldner - Ling Peng - 1‐( o ‐Nitrophenyl)‐2,2,2‐trifluoroethyl Ether Derivatives as Stable and Efficient Photoremovable Alcohol‐Protecting Groups, Angewandte Chemie International Edition | 2004
Co-auteur(s) : Alexandre Specht - Maurice Goeldner - Kinetic crystallography on cholinesterases, Acta Crystallographica Section A Foundations of Crystallography | 2004
Co-auteur(s) : J. P. Colletier - A. Royant - Alexandre Specht - F. Nachon - G. Zaccai - Maurice Goeldner - J. L. Sussman - D. Bourgeois - M. Weik - Mutually Induced Formation of Host–Guest Complexes between p ‐Sulfonated Calix[8]arene and Photolabile Cholinergic Ligands, Angewandte Chemie International Edition | 2002
Co-auteur(s) : Alexandre Specht - Philippe Bernard - Maurice Goeldner - Ling Peng - p-Hydroxyphenacyl bromide as photoremoveable thiol label: a potential phototrigger for thiol-containing biomolecules, Tetrahedron Letters | 2002
Co-auteur(s) : Alexandre Specht - Sandra Loudwig - Ling Peng - Maurice Goeldner - Cryophotolysis of ortho-Nitrobenzyl Derivatives of Enzyme Ligands for the Potential Kinetic Crystallography of Macromolecules, ChemBioChem | 2001
Co-auteur(s) : Alexandre Specht - Thomas Ursby - Martin Weik - Ling Peng - Jan Kroon - Dominique Bourgeois - Maurice Goeldner - Characterization of Caged Cholinergic Ligands; Sulfonated Calix[4]arene Inclusion Complexes, Synlett | 1999
Co-auteur(s) : Alexandre Specht - Maurice Goeldner - Jakob Wirz - Ling Peng
Conférences
- Optical dissection of gating in P2X receptors, Purinergic Signalling | 2014
Co-auteur(s) : Chloé Habermacher - Damien Lemoine - Adeline Martz - Alexandre Specht - Thomas Grutter - Optogating a powerful approach to control an ion-channel gate, Purinergic Signalling | 2014
Co-auteur(s) : Damien Lemoine - Chloe Habermacher - Adeline Martz - Pierre-Francois Mery - Nathalie Bouquier - Fanny Diverchy - Antoine Taly - Francois Rassendren - Alexandre Specht - Thomas Grutter - Temperature-controlled crystallographic experiments on acetylcholinesterase, Acta Crystallographica Section A Foundations of Crystallography | 2000
Co-auteur(s) : M. Weik - T. Ursby - D. Bourgeois - R. Ravelli - S. McSweeney - Ling Peng - Alexandre Specht - M. Goeldner - G. Kryger - I. Silman - J. Sussman