Jean-Serge Remy

Biographie courte CV

Jean-Serge Remy est Directeur de recherche au CNRS.

Quelques éléments de carrière :

Thèse en en Pharmaco-Chimie dans l’équipe de « Chimie Génétique » du Dr. Jean-Paul Behr (1990-1994), sur le transfert de gènes à l’aide de lipides cationiques.
Post-doctorat à l’Université de Californie San Francisco (UCSF), dans le laboratoire du Pr. Francis D. Szoka Jr. (1995).
Chercheur CNRS depuis 1995.
Directeur de l’équipe « Chimie Génétique » (2006-2012).
Co-fondateur et membre du LabEx Medalis (2012-2017).
Directeur adjoint de l’UMR 7199 (CAMB ; 2012), puis Directeur (2013-2023).
Membre du comité de pilotage de l’icFRC (2013-2023).
Directeur-adjoint de l’École Doctorale de Chimie ED 222 (2014-2016), puis Directeur (2017-2019).

74 publications disponibles

Articles scientifiques
Parties d'ouvrages
Productions de vulgarisation

Articles scientifiques

Supramolecular Bioconjugation Strategy for Antibody-Targeted Delivery of siRNA, Bioconjugate Chemistry | 2024
Co-auteur(s) : Manon Ripoll - Heloise Cahuzac - Igor Dovgan - Sylvain Ursuegui - Patrick Neuberg - Stéphane Erb - Sarah Cianferani - Antoine Kichler - Alain Wagner
Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy, Frontiers in Chemistry | 2020
Co-auteur(s) : Boris Gaillard - Francoise Pons-lebeau - Luc Lebeau
Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs, Pharmaceutical Research | 2020
Co-auteur(s) : Boris Gaillard - Francoise Pons-lebeau - Luc Lebeau
Design and evaluation of ionizable peptide amphiphiles for siRNA delivery, International Journal of Pharmaceutics | 2019
Co-auteur(s) : Patrick Neuberg - Alain Wagner - Antoine Kichler
Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy, Chemistry – A European Journal | 2019
Co-auteur(s) : Boris Gaillard - Cendrine Seguin - Françoise Pons - Luc Lebeau
Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids, Molecular Therapy - Nucleic Acids | 2018
Co-auteur(s) : Marc Nothisen - Phanélie Perche-Létuvée - Jean-Paul Behr - Mitsuharu Kotera
Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing, RSC Advances | 2018
Co-auteur(s) : Manon Ripoll - Marie Pierdant - Patrick Neuberg - Dominique Bagnard - Alain Wagner - Antoine Kichler
Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery, Nanoscale | 2018
Co-auteur(s) : Patrick Neuberg - Imene Hamaidi - Sabrina Danilin - Manon Ripoll - Veronique Lindner - Marc Nothisen - Alain Wagner - Antoine Kichler - Thierry Massfelder
From solution to in-cell study of the chemical reactivity of acid sensitive functional groups, Organic and Biomolecular Chemistry | 2016
Co-auteur(s) : Sylvain Jacques - Geoffray Leriche - Michel Mosser - Marc Nothisen - Christian Muller - Alain Wagner
From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release, Organic and Biomolecular Chemistry | 2016
Co-auteur(s) : Sylvain A. Jacques - Geoffray Leriche - Michel Mosser - Marc Nothisen - Christian Muller - Alain Wagner
Preparation of poly(ethylene imine) derivatives with precisely controlled molecular weight, European Polymer Journal | 2016
Co-auteur(s) : Matthieu Landa - Mitsuharu Kotera - Nezha Badi
Structure Tuning of Cationic Oligospermine–siRNA Conjugates for Carrier-Free Gene Silencing, Molecular Pharmaceutics | 2016
Co-auteur(s) : Marc Nothisen - Jérémy Bagilet - Jean-Paul Behr - Mitsuharu Kotera
Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection, Nature Chemistry | 2016
Co-auteur(s) : Antonio Munoz - David Sigwalt - Beatriz Illescas - Joanna Luczkowiak - Laura Rodriguez-Perez - Iwona Nierengarten - Michel Holler - Kevin Buffet - Stéphane Vincent - Javier Rojo - Rafael Delgado - Jean-françois Nierengarten - Nazario Martin
pH-Responsive Nanometric Polydiacetylenic Micelles Allow for Efficient Intracellular siRNA Delivery, ACS Applied Materials and Interfaces | 2016
Co-auteur(s) : Manon Ripoll - Patrick Neuberg - Antoine Kichler - Nassera Tounsi - Alain Wagner
Mannoside Glycolipid Conjugates Display Anti-inflammatory Activity by Inhibition of Toll-like Receptor-4 Mediated Cell Activation, ACS Chemical Biology | 2015
Co-auteur(s) : Vincent Flacher - Patrick Neuberg - Floriane Point - François Daubeuf - Quentin Muller - David Sigwalt - Jean-Daniel Fauny - Nelly Frossard - Alain Wagner - Christopher G Mueller - Evelyne Schaeffer
Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties, Chemical Communications | 2015
Co-auteur(s) : Patrick Neuberg - Aurelia Perino - Emmanuelle Morin-Picardat - Nicolas Anton - Zeinab Darwich - Denis Weltin - Yves Mely - Andrey Klymchenko - Alain Wagner
Spiro Diorthoester (SpiDo), a Human Plasma Stable Acid-Sensitive Cleavable Linker for Lysosomal Release, Bioconjugate Chemistry | 2015
Co-auteur(s) : Geoffray Leriche - Marc Nothisen - Nadege Baumlin - Christian Muller - Dominique Bagnard - Sylvain Jacques - Alain Wagner
Bio-specific and bio-orthogonal chemistries to switch-off the quencher of a FRET-based fluorescent probe: application to living-cell biothiol imaging, Chemical Communications | 2014
Co-auteur(s) : Coraline Egloff - Sylvain Jacques - Marc Nothisen - D Weltin - C Calligaro - Michel Mosser - Alain Wagner
Selective Irreversible Chemical Tagging of Cysteine with 3-Arylpropiolonitriles, Bioconjugate Chemistry | 2014
Co-auteur(s) : Oleksandr Koniev - Geoffray Leriche - Marc Nothisen - Jean Marc Strub - Christine Schaeffer-Reiss - Alain Van Dorsselaer - Rachid Baati - Alain Wagner
Cell-penetrating cationic siRNA and lipophilic derivatives efficient at nanomolar concentrations in the presence of serum and albumin, Journal of Controlled Release | 2013
Co-auteur(s) : Phanelie Perche - Marc Nothisen - Jeremy Bagilet - Jean-Paul Behr - Mitsuharu Kotera
Dynamic Micelles of Mannoside Glycolipids are more Efficient than Polymers for Inhibiting HIV-1 trans-Infection, Bioconjugate Chemistry | 2013
Co-auteur(s) : Evelyne Schaeffer - Laure Dehuyser - David Sigwalt - Vincent Flacher - Serena Bernacchi - Olivier Chaloin - Christopher G Mueller - Rachid Baati - Alain Wagner
Dynamic Micelles of Mannoside Glycolipids are more Efficient than Polymers for Inhibiting HIV-1 trans-infection., Bioconjugate Chemistry | 2013
Co-auteur(s) : Evelyne Schaeffer - Laure Dehuyser - David Sigwalt - Vincent Flacher - Serena Bernacchi - Olivier Chaloin - Christopher G Mueller - Rachid Baati - Alain Wagner
Polycationic Pillar 5 arene Derivatives: Interaction with DNA and Biological Applications, Chemistry - A European Journal | 2013
Co-auteur(s) : Iwona Nierengarten - Marc Nothisen - David Sigwalt - Thomas Biellmann - Michel Holler - Jean-Francois Nierengarten
Cationic Polydiacetylene Micelles for Gene Delivery, Bioconjugate Chemistry | 2011
Co-auteur(s) : Emmanuelle Morin - Marc Nothisen - Alain Wagner
Gene delivery with polycationic fullerene hexakis-adducts, Chemical Communications | 2011
Co-auteur(s) : David Sigwalt - Michel Holler - Julien Iehl - Jean-françois Nierengarten - Marc Nothisen - Emmanuelle Morin
MMT, Npeoc-protected spermine, a valuable synthon for the solid phase synthesis of oligonucleotide oligospermine conjugates via guanidine linkers, Bioorganic and Medicinal Chemistry | 2011
Co-auteur(s) : Phanelie Perche - Mitsuharu Kotera
Adenovirus-derived vectors for prostate cancer gene therapy., Human Gene Therapy | 2010
Co-auteur(s) : J de Vrij - R Willemsen - L Lindholm - R Hoeben - G Consortium - C Bangma - C Barber - J Behr - S Briggs - R Carlisle - W Cheng - I Dautzenberg - C de Ridder - H Dzojic - P Erbacher - M Essand - K Fisher - A Frazier - L Georgopoulos - I Jennings - S Kochanek - D Koppers-Lalic - R Kraaij - F Kreppel - M Magnusson - N Maitland - P Neuberg - R Nugent - M Ogris - M Scaife - E Schenk-Braat - E Schooten - L Seymour - M Slade - P Szyjanowicz - T Totterman - T Uil - K Ulbrich - L van der Weel - W van Weerden - E Wagner - G Zuber
Fine-Tuning the Morphology of Self-Assembled Nanostructures of Propargyl Ammonium-Based Amphiphiles, The Journal of Physical Chemistry B | 2010
Co-auteur(s) : Emmanuelle Morin - Jean-Michel Guenet - David D. Díaz - Alain Wagner
Proton Sponge Trick for pH-Sensitive Disassembly of Polyethylenimine-Based siRNA Delivery Systems, Bioconjugate Chemistry | 2010
Co-auteur(s) : Gaelle Creusat - Anne-Sophie Rinaldi - Etienne Weiss - Rkia Elbaghdadi - Rita Mulherkar - Guy Zuber
Tailoring drug release profile of low-molecular-weight hydrogels by supramolecular co-assembly and thiol-ene orthogonal coupling, Journal of Materials Chemistry | 2010
Co-auteur(s) : David Diaz - Emmanuelle Morin - Eva Schoen - Ghyslain Budin - Alain Wagner
Cationic siRNAs Provide Carrier-Free Gene Silencing in Animal Cells, Journal of the American Chemical Society | 2009
Co-auteur(s) : Marc Nothisen - Mitsuharu Kotera - Emilie Voirin - Jean-Paul Behr
Zip Nucleic Acids: new high affinity oligonucleotides as potent primers for PCR and reverse transcription, Nucleic Acids Research | 2009
Co-auteur(s) : Valérie Moreau - Emilie Voirin - Clément Paris - Mitsuharu Kotera - Marc Nothisen - Jean-Paul Behr - Patrick Erbacher - Nathalie Lenne-Samuel
Oligonucleotide−Oligospermine Conjugates (Zip Nucleic Acids): A Convenient Means of Finely Tuning Hybridization Temperatures, Journal of the American Chemical Society | 2008
Co-auteur(s) : Régis Noir - Mitsuharu Kotera - Bénédicte Pons - Jean-Paul Behr
A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin, The Journal of Gene Medicine | 2004
Co-auteur(s) : Idit Kopatz - Jean-Paul Behr
Effective polyethylenimine-mediated gene transfer into human endothelial cells, The Journal of Gene Medicine | 2004
Co-auteur(s) : Violeta Zaric - Denis Weltin - Patrick Erbacher - Jean-Paul Behr - Dominique Stephan
Genuine DNA/polyethylenimine (PEI) Complexes Improve Transfection Properties and Cell Survival, Journal of Drug Targeting | 2004
Co-auteur(s) : Patrick Erbacher - Thierry Bettinger - Emmanuel Brion - Jean-Luc Coll - Christian Plank - Jean-Paul Behr
The Magnetofection Method: Using Magnetic Force to Enhance Gene Delivery, Biological Chemistry | 2003
Co-auteur(s) : Christian Plank - Ulrike Schillinger - Franz Scherer - Christian Bergemann - Florian Krötz - Marina Anton - Jim Lausier - Joseph Rosenecker
Development of plasmid and oligonucleotide nanometric particles, Gene Therapy | 2002
Co-auteur(s) : Emmanuel Dauty - Jean-Paul Behr
Intracellular Delivery of Nanometric DNA Particles via the Folate Receptor, Bioconjugate Chemistry | 2002
Co-auteur(s) : Emmanuel Dauty - Guy Zuber - Jean-Paul Behr
Intracellular delivery of nanometric DNA particles via the folate receptor, Bioconjugate Chemistry | 2002
Co-auteur(s) : Emmanuel Dauty - Guy Zuber - Jean-Paul Behr
Dimerizable Cationic Detergents with a Low cmc Condense Plasmid DNA into Nanometric Particles and Transfect Cells in Culture, Journal of the American Chemical Society | 2001
Co-auteur(s) : Emmanuel Dauty - Thomas Blessing - Jean-Paul Behr
Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver, Gene Therapy | 2001
Co-auteur(s) : M Robaczewska - S Guerret - I Chemin - W-B Offensperger - M Chevallier - Jean-Paul Behr - A J Podhajska - H E Blum - C Trepo - L Cova
Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity, Gene Therapy | 2001
Co-auteur(s) : K Aoki - S Furuhata - K Hatanaka - M Maeda - Jean-Paul Behr - M Terada - T Yoshida
Dimerizable Detergents as Gene Transfer Vectors, Journal of Liposome Research | 2000
Co-auteur(s) : Thomas Blessing - Emmanuel Dauty - Jean-Paul Behr
Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery, Gene Therapy | 2000
Co-auteur(s) : D Finsinger - P Erbacher - C Koch - C Plank
Systemic linear polyethylenimine (L‐PEI)‐mediated gene delivery in the mouse, Journal of Gene Medicine | 2000
Co-auteur(s) : Shao-Min Zou - Patrick Erbacher - Jean-Paul Behr
The p21 cip1/waf1 cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells, Cancer Letters | 2000
Co-auteur(s) : H. Lincet - L. Poulain - E. Deslandes - C. Duigou - P. Gauduchon - C. Staedel
Controlled Template-Assisted Assembly of Plasmid DNA into Nanometric Particles with High DNA Concentration, Bioconjugate Chemistry | 1999
Co-auteur(s) : Ming Ouyang - Francis C. Szoka
Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway, Gene Therapy | 1999
Co-auteur(s) : Patrick Erbacher - Jean-Paul Behr
Polyethylenimine but Not Cationic Lipid Improves Antisense Activity of 3′-Capped Phosphodiester Oligonucleotides, Antisense and Nucleic Acid Drug Development | 1999
Co-auteur(s) : Sonia Dheur - Nathalie Dias - Arthur Van Aerschot - Piet Herdewijn - Thierry Bettinger - Claude Hélène - E. Tula Saison-Behmoaras
Size Reduction of Galactosylated PEI/DNA Complexes Improves Lectin-Mediated Gene Transfer into Hepatocytes, Bioconjugate Chemistry | 1999
Co-auteur(s) : Thierry Bettinger - Patrick Erbacher
Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody‐derivatized polyethylenimines (PEI), Journal of Gene Medicine | 1999
Co-auteur(s) : Patrick Erbacher - Thierry Bettinger - Pascale Belguise-Valladier - Shaomin Zou - Jean-Luc Coll - Jean-Paul Behr
Chitosan-Based Vector/DNA Complexes for Gene Delivery: Biophysical Characteristics and Transfection Ability, Pharmaceutical Research | 1998
Co-auteur(s) : Patrick Erbacher - Shaomin Zou - Thierry Bettinger - Anne‐Marie Steffan
Convenient Polymer-Supported Synthetic Route to Heterobifunctional Polyethylene Glycols, Bioconjugate Chemistry | 1998
Co-auteur(s) : Thierry Bettinger - Patrick Erbacher - Jean-Paul Behr
Gene transfer with lipospermines and polyethylenimines, Advanced Drug Delivery Reviews | 1998
Co-auteur(s) : Bassima Abdallah - Maria Antonietta Zanta - Otmane Boussif - Jean-Paul Behr - Barbara Demeneix
Monomolecular collapse of plasmid DNA into stable virus-like particles, Proceedings of the National Academy of Sciences | 1998
Co-auteur(s) : Thomas Blessing - Jean-Paul Behr
Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells, Journal of Biological Chemistry | 1998
Co-auteur(s) : Hélène Pollard - Gildas Loussouarn - Sophie Demolombe - Jean-Paul Behr - Denis Escande
Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system, Gene Therapy | 1998
Co-auteur(s) : Daniel Goula - Patrick Erbacher - M Wasowicz - G Levi - B Abdallah - BA Demeneix
Template Oligomerization of DNA-Bound Cations Produces Calibrated Nanometric Particles, Journal of the American Chemical Society | 1998
Co-auteur(s) : Thomas Blessing - Jean-Paul Behr
Delivery of Polynucleotides with Polyamine Lipids and Polymers, Nucleosides and Nucleotides | 1997
Co-auteur(s) : B. A. Demeneix - Otmane Boussif - Maria Antonietta Zanta - Jean-Paul Behr
Lipospermine-mediated gene transfer technique into murine cultured cortical cells, Journal of Neuroscience Methods | 1997
Co-auteur(s) : Brigitte Sola - Cathy Staedel - Amina Bahr - Jean-paul Behr
Gene Transfer with Multivalent Synthetic Vectors, Journal of Liposome Research | 1996
Co-auteur(s) : Jean-Paul Behr
Efficient Gene Delivery with Neutral Complexes of Lipospermine and Thiol-Reactive Phospholipids, Biochemical and Biophysical Research Communications | 1995
Co-auteur(s) : Antoine Kichler - Otmane Boussif - Benoît Frisch - Christophe Boeckler - Jean-Paul Behr - Francis Schuber
Synthesis and Evaluation as a Gene Transfer Agent of a 1,2-Dimyristoyl-glycero-3-pentalysine Salt, Chemistry Letters | 1995
Co-auteur(s) : Jean-Marc Weibel - Antoine Kichler - Christian Gaiddon - Jean-Philippe Loeffler - Guy Duportail - Denis Heissler
Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses., Proceedings of the National Academy of Sciences | 1995
Co-auteur(s) : Antoine Kichler - V. Mordvinov - Francis Schuber - Jean-Paul Behr
Gene Transfer with a Series of Lipophilic DNA-Binding Molecules, Bioconjugate Chemistry | 1994
Co-auteur(s) : Claude Sirlin - Pierre Vierling - Jean-Paul Behr
High-Efficiency Transfection of Primary Human Keratinocytes with Positively Charged Lipopolyamine: DNA Complexes, Journal of Investigative Dermatology | 1994
Co-auteur(s) : Cathy Staedel - Zhongxue Hua - Thomas R Broker - Louise T Chow - Jean-Paul Behr
Gene Transfer Optimization with Lipospermine-Coated DNA, DNA and Cell Biology | 1993
Co-auteur(s) : Fabrice Barthel - Jean-Philippe Loeffler - Jean-Paul Behr

Parties d'ouvrages

Cationic Photopolymerized Polydiacetylenic (PDA) Micelles for siRNA Delivery, Nanotechnology for Nucleic Acid Delivery | 2019
Co-auteur(s) : Manon Ripoll - Patrick Neuberg - Antoine Kichler
Virus-like nanoparticles for Gene Therapy, Smart nanoparticles in nanomedicine | 2006
Co-auteur(s) : Guy Zuber - D. Dalkara
Molecular Vectors for Gene Delivery to Cancer Cells, Nucleic Acid Therapeutics in Cancer | 2004
Co-auteur(s) : Guy Zuber - Patrick Erbacher - Pascale Belguise - Jean-Paul Behr
Taking lipospermines and polyethylenimine from in vitro to in vivo, Self-assembling complexes for gene delivery: From laboratory to clinical trial | 1998
Co-auteur(s) : Daniel Goula - Anne-Marie Steffan - Maria Antonietta Zanta - Otmane Boussif - Jean-Paul Behr - Barbara Demeneix
Gene transfer with cationic amphiphiles, Liposomes in basic research and industry | 1995
Co-auteur(s) : Claude Sirlin - Jean-Paul Behr