Publications

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2024

  • Triplet-Triplet Annihilation Upconversion Based Photolysis: Applications in Photopharmacology, M. Klimezak, J. Chaud, A. Brion, F. Bolze, B. Frisch, B. Heurtault, A. Kichler, A. Specht, Adv. Healthcare Mater.2024, 2400354.
  • β-β-alkynyl-bridged BODIPY dimers: Synthesis, one- and two-photon photophysical properties, M. Zhu, T. Gu, C.P. Gros, F. Bolze, X. Liang, Y. Chang, H. Xu β-β-alkynyl-bridged BODIPY dimers: Synthesis, one- and two-photon photophysical properties. Journal of Molecular Structure, 2024, 1310, 138313.
  • Reduction of Pro-Inflammatory Markers in RAW264.7 Macrophages by Polyethylenimines, E. Frisch, C. Dussouillez, C. McCartin, J. Blumberger, C. Humbert, L. Lebeau, B. Frisch, B. Heurtault, A. Kichler, S. Fournel, Macromol. Biosci.2024, 2300492.
  • Towards a light-mediated gene therapy for the eye - retinal transgene expression through photoactivation of caged ethinylestradiol and the inducible Cre/lox system, Z. Kiy, J. Chaud, L. Xu, E. Brandhorst, T. Kamali, H. Hong, A. Specht, S. Cambridge, Angew Chem Int Ed,2024, e202317675.
  • Synthesis, X-Ray and DFT studies, one- and two-photon photophysical properties, Y. Jin, Z. Chai, Y. Rousselin, J.-T. Pouzens, P. Fleurat-Lessard, C. P. Gros, A. Beau, F. Bolze and H.-J. Xu, Dyes and Pigments, 2024, 222, 111866.
  • Synthesis and photochemical properties of fluorescent metabolites generated from fluorinated benzoylmenadiones in living cells, N. Trometer, B. Cichocki, Q. Chevalier, J. Pécourneau, J-M Strub,A. Hemmerlin, A. Specht, E. Davioud-Charvet,Mourad Elhabiri, J Org Chem, 2024, 89, 4, 2104–2126.

2023

  • The interplay between lysosome, protein corona and biological effects of cationic carbon dots: role of surface charge titratability. Y. Arezki, E. Harmouch, F. Delalande, M. Rapp, C. Schaeffer-Reiss, O. Galli, S. Cianférani, L. Lebeau, F. Pons, C. Ronzani, Int J Pharm 2023, 123388.
  • Photoactivatable liposomes for blue to deep red light activated surface drug release: application to controlled delivery of the antitumoral drug melphalan, A. Brion, J. Chaud, M. Pascouau, F. Bolze, L. Ohlmann, J. Léonard, S. Chassaing, B. Frisch, A. Kichler, B. Heurtault, A. Specht, Bioconjugate Chem.2023, 34, 7, 1304–1315.
  • Wavelength-Dependent, Orthogonal Photoregulation of DNA Functions for Logic Computation, L.S. Liu, H.M. Leung, C. Morville, H. C. Chu, T. Chang, T., Juin Han Y. Jing, A. Specht, F. Bolze, P.K. Lo, ACS Appl Mater Interfaces,2023, 15, 1, 1944–1957.
  • Red Light-Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin-Based Prodrug, A. Brion, J. Chaud, J. Léonard, F. Bolze, S. Chassaing, B. Frisch, B; Heurtault, A. Kichler, A. Specht, Adv Health Mat, 2023,12(2):e2201474.
  • Teaching with Arduino: Porphyrinoids’ fluorescence in olive oil, F. Bolze, Journal of Porphyrins and Phthalocyanines 2023, 27, 1177-1181.
  • Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labelling in live cells, M. Auvray, D. Naud-Martin, G. Fontaine, F. Bolze, G. Clavier and F. Mahuteau-Betzer, Chemical Science, 2023, 14, 8119-8128.

2022

  • Surface charge influences protein corona, cell uptake and biological effects of carbon dots. Y. Arezki, F. Delalande, C. Schaeffer, M. Rapp, L. Lebeau, F. Pons, C. Ronzani, Nanoscale 2022, 14, 14695.
  • Cationic carbon nanoparticles induce inflammasome-dependent pyroptosis in macrophages via lysosomal dysfunction. Y. Arezki, M. Rapp, L. Lebeau, C. Ronzani, F. Pons, Front Toxicol 2022, 4, 925399.
  • Mucus producing epithelial models for investigating the activity of gene delivery systems in the lung. T. Sonntag, M. Rapp, P. Didier, L. Lebeau, F. Pons, A. Casset, Int J Pharm2022, 614, 121423.
  • Synthesis, spectroscopic characterization, one and two-photon absorption properties of β-β linked BODIPY dimers,Y. Wang, Y. Rousselin, C. P. Gros, F. Bolze, X. Liang, W. Zhu, H. Xu, Dyes and Pigments, 2022, 206, 110601.
  • Synthesis, photophysical properties and two-photon absorption of benzothiazole/benzoxazole π-expanded carbazole dyes,L. Sun, X. Wang, P. Fleurat-Lessard, C. P. Gros, F. Bolze, H. Xu, Dyes and Pigments, 2022, 204, 110447.
  • On the Road Toward More Efficient Biocompatible Two-Photon Excitable Fluorophores, M. Auvray, F. Bolze, D. Naud-Martin, M. Poulain, M. Bossuat, G. Clavier and F. Mahuteau-Betzer, Chemistry – A European Journal, 2022, 28, e202104378.
  • New 1,4-divinylbenzene conjugated truxene dyes possessing D-π-D structure: Synthesis, linear photophysics and two-photon absorption, Y. Wang, X. Kang, F. Cai, L. Sun, Y. Yu, C. P. Gros, F. Bolze and H. Xu, Journal of Luminescence, 2022, 242, 118579.

2021

  • Photolytical reactions for light induced biological effectors release: on the road to the phototherapeutic window, C. Morville, J. Chaud, B. Bolze, A. Specht, J Incl Phenom Macrocycl Chem, 2021, 101, 291–304.
  • Two-Photon Sensitive Coumarinyl Photoremovable Protecting Groups with Rigid Electron-Rich Cycles Obtained by Domino Reactions Initiated by a 5-exo-Dig Cyclocarbopalladation, J. Chaud, C. Morville, F. Bolze, D. Garnier, S. Chassing, G. Blond, A. Specht, Org Lett 2021, 23, 19, 7580–7585.
  • A co-culture model of the human respiratory tract to discriminate the toxicological profile of cationic nanoparticles according to their surface charge density. Y. Arezki, J. Cornacchia, M. Rapp, L. Lebeau, F. Pons, C. Ronzani, Toxics 2021, 9, 210.
  • The pH-induced specific area changes of unsaturated lipids deposited onto a bubble interface. Anton, N.; Pierrat, P.; Brou, G. A.; Gbassi, G. K.; Omran, Z.; Lebeau,L.; Vandamme, T. F.; Bouriat, P. Langmuir2021, 37, 2586-2595.-
  •  Combined in vitro and in vivo approaches to propose a putative adverse outcome pathway for acute lung inflammation induced by nanoparticles: a study on carbon dots. M. Weiss, J. Fan, M. Claudel, L. Lebeau, F. Pons, C. Ronzani, Nanomaterials2021, 11, 180.
  • Density of surface charge is a more predictive factor of the toxicity of cationic nanoparticles than zeta potential. M. Weiss, J. Fan, M. Claudel, T. Sonntag, P. Didier, C. Ronzani, L. Lebeau, F. Pons, J Nanobiotech2021, 19, 5.
  • Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders. J.K. Venkatesan, A. Rey-Rico, W. Meng, X. Cai, F. Pons, L. Lebeau, V. Migonney, H. Madry, M. Cucchiarini, Mater Today Adv2021, 9, 100126.
  • Silafluorene as a promising core for cell-permeant, highly bright and two-photon excitable fluorescent probes for live-cell imaging, M. Auvray, F. Bolze, G. Clavier, F. Mahuteau-Betzer, Dyes and Pigments,2021, 187, 109083.
  • Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid-β in an Alzheimer’s Disease Mouse Model, X. Wang, H.N. Chan, N. Desbois, C. P. Gros, F. Bolze, Y. Li, H. W. Li, M. S. Wong, ACS Applied Materials & Interfaces, 2021, 13 (16), 18525-18532.
  • Synthesis, spectroscopic characterization and one and two-photon absorption properties of π-expanded thiophene and truxene BODIPYs dyes, P. Li, D. Sun, N. Liu, Y. Fang, C. P. Gros, F. Bolze, H.-J.Xu, Dyes and Pigments, 2021, 192, 109418.

2020

  • Dual gene delivery reagents from antiproliferative alkyphospholipids for combined antitumor therapy. B. Gaillard, J-S. Remy, F. Pons, L. Lebeau, Front Chem 2020, 8, 581260.
  • Synthesis and evaluation of antitumor alkylphospholipid prodrugs. B. Gaillard, JS. Remy, F. Pons, L. Lebeau, Pharm Res 2020, 37, 106.
  • rAAV-mediated overexpression of SOX9 and TGF-b via carbon dot-guided vector delivery enhances the biological activities in human bone marrow-derived mesenchymal stromal cells. W. Meng, A. Rey-Rico, M. Claudel, G. Schmitt, S. Speicher-Mentges, F. Pons, L. Lebeau, JK. Venkatesan, M. Cucchiarini,Nanomaterials2020, 10, 855.
  • Development and characterization of layer-by-layer coated liposomes with poly(L-lysine) and poly(L-glutamic acid) to increase their resistance in biological media, F. Hermal B. Frisch, A. Specht, L. Bourel-Bonnet, B. Heurtault, J Pharm2020, 30;586:119568.
  • Monitoring of uncaging processes by designing photolytical reactions, E. Abou Nakad, J. Chaud, C. Morville, F. Bolze, A. Specht,  Photochemical & Photobiological Sciences 2020, 19 (9), 1122-1133.
  • Synthesis, spectroscopic characterization, one and two-photon absorption properties and electrochemistry of π-expanded BODIPYs dyes, J. Yang, F. Cai, N. Desbois, L. Huang, C. P. Gros, F. Bolze, Y. Fang, S. Wang, H.-J. Xu. Dyes and Pigments, 2020, 175, 108173.
  • Synthesis, spectroscopic characterization, one and two-photon absorption properties, and electrochemistry of truxene π-expanded BODIPYs dyes, J. Yang, H. Jiang, N. Desbois, G. Zhu, C. P. Gros, Y. Fang, F. Bolze, S. Wang, H.-J. Xu, Dyes and Pigments 2020,176, 108183.
  • Truxene-BODIPY dyads and triads: Synthesis, spectroscopic characterization, one and two-photon absorption properties and electrochemistry, X. Xu, D. Sun, J. Yang, G. Zhu, Y. Fang, C. P. Gros, F. Bolze, H.-J. Xu, Dyes and Pigments 2020,179, 108380.
  • Synthesis and In Vitro Studies of a Gd(DOTA)–Porphyrin Conjugate for Combined MRI and Photodynamic Treatment, S. Jenni, F. Bolze, C. S. Bonnet, A. Pallier, A Sour, E Tóth, B. Ventura, V. Heitz, Inorganic Chemistry 2020,59 (19), 14389-14398.

2019

  • Erufosine (ErPC3) cationic prodrugs as dual gene delivery reagents for combined antitumor therapy. B. Gaillard, C. Seguin, JS. Remy, F. Pons, L. Lebeau, Chem-Eur J2019, 25,15662-15679.
  • Physicochemical characteristics that affect carbon dot safety: Lessons from a comprehensive study on a nanoparticle library. J. Fan, M. Claudel, C. Ronzani, Y. Arezki, L. Lebeau, F. Pons, Int J Pharm2019, 118521.
  • Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders. G. Aubertin, M. Weiss, F. Traversi, D. Benameur, P. Choquet, N. Dali-Youcef, F. Pons, S. Sigrist, H. Greney, L. Monassier, P. Bousquet, N. Niederhoffer N. Int J Obes2019.
  • Influence of carbonization conditions on luminescence and gene delivery properties of nitrogen-doped carbon dots. M. Claudel, J. Fan, M. Rapp, F. Pons, L. Lebeau, RSC Adv2019, 9:3493-3502.
  • Macrophage functionality and homeostasis in response to oligoethyleneglycol-coated IONPs: Impact of a dendritic architecture. A. Casset, J. Jouhannaud, A. Garofalo, C. Spiegelhalter, DV. Nguyen, D. Felder-Flesch, G. Pourroy, F. Pons, Int J Pharm 2019, 556:287-300.
  • Lysosome mediates toxicological effects of polyethyleneimine-based cationic carbon dots. C. Ronzani, C. Van Belle,P. Didier, C. Spiegelhalter, P. Pierrat, L. Lebeau, F. Pons, J Nanopart Res 2019, 21:4.
  • Tumour-targeting photosensitisers for one- and two-photon activated photodynamic therapy. S. Jenni, A. Sour, F. Bolze, B. Ventura, V. Heitz, Organic & Biomolecular Chemistry2019, 17 (27), 6585-6594.
  • Tuning the pKa of two-photon bis-chromophoric probes for ratiometric fluorescence imaging of acidic pH in lysosomes, T. Zhang, D. Xu, C. Y. Poon,  X. Wang, F. Bolze, H.-W. Li, M. S. Wong, Talanta 2019,202, 34-41.

2018

  • Encapsulation of S-nitrosoglutathione: a transcriptomic validation, R. Safar, R. Houlgatte, A. Le Faou, C. Ronzani, W. Wu, L. Ferrari, H. Dubois-Pot-Schneider,  BH. Rihn, O. Joubert, Drug Dev Ind Pharm2018, 17:1-28.
  • High-frequency stimulation of normal and blind mouse retinas Using TiO2 nanotubes. C. Ronzani, T. Cottineau, I. Gonzalez-Valls, V. Keller, S. Picaud, N. Keller, MJ. Roux, Adv Funct Mater 2018, 28:1804639.
  • o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties, E. Abou Nakad, F. Bolze, A. Specht, A. Organic & Biomolecular Chemistry 2018,16 (33), 6115-6122.
  • Synthesis and characterization of photoactivatable doxycycline analogues bearing two-photon-sensitive photoremovable groups suitable for light-induced gene expression, B. Goegan, F. Terzi, F. Bolze, S. Cambridge, A. Specht, Chembiochem2018, 8;19(12):1341-1348.
  • Two-Photon Absorption Properties and Structures of BODIPY and Its Dyad, Triad and Tetrad, J. Yang, Y. Rousselin, L. Bucher, N. Desbois, F. Bolze, H.-J. Xu, C. P. Gros, ChemPlusChem2018, 83 (9), 838-844.
  • A Porphyrin Dimer–GdDOTA Conjugate as a Theranostic Agent for One- and Two-Photon Photodynamic Therapy and MRI, J. Schmitt, S. Jenni, A. Sour, V. Heitz, F. Bolze, A. Pallier, C.S. Bonnet, E. Tóth, B. Ventura, Bioconjugate Chemistry, 2018,29 (11), 3726-3738.

2017

  • Molecular photosensitisers for two-photon photodynamic therapy, F. Bolze, S. Jenni, A. Sour, V. Heitz, Chem Commun ,  2017,53, 12857-12877.
  • On the permeation of large organic cations through the pore of ATP-gated P2X receptors, M. Harkat, M., Peverini, L., Cerdan, A. H.,  Dunning, K., Beudez, J., Martz, A., Calimet, N., Specht, A., Cecchini, M., Chataigneau, T., Grutter, Proc Natl Acad Sci U S A, 2017,114, E3786-E3795.
  • π-extended porphyrin dimers as efficient near-infrared emitters and two-photon absorbers, J. Schmitt, V. Heitz, S. Jenni, A. Sour, F. Bolze, B. Ventura, Supramolecular Chemistry, 2017, 29, 769-775.

2016

  • Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel, C. Habermacher, A. Martz, N. Calimet, D. Lemoine, L. Peverini, A. Specht, M. Cecchini, T. Grutter, eLife, 2016, 5, e11050.
  • A theranostic agent combining a two-photon-absorbing photosensitizer for photodynamic therapy and a gadolinium(III) complex for MRI detection, J. Schmitt, V. Heitz, A. Sour, F. Bolze, P. Kessler, L. Flamigni, B. Ventura, C. S. Bonnet, E. Toth, Chem Eur, 2016, 22, 2775-86.
  • A reversible DNA logic gate platform operated by one- and two-photon excitations, D. Y. Tam, Z. Dai, M. S. Chan, L. S.  Liu, M. C.  Cheung, F. Bolze, C. Tin, P. K. Lo, Angew Chem Int Ed,2016,  55, 164-8.
  • Two-photon sensitive photolabile protecting groups : From molecular engineering to nanostructuration, S. Piant, A. Specht, B. Zemelman, A. Losonczy, F. Bolze, Mol Cryst Liquid Cryst2016, 627, 1-10.
  • Piant, S., Bolze, F., and Specht, A., (2016) Two-photon uncaging, from neuroscience to materials. Opt. Mater. Express, 6(5), 1679−1691.
  • Three−Dimensional Control of DNA Hybridization by Orthogonal Two−Color Two−Photon Uncaging, M. AH. Fichte, X. MM., Weyel, S. Junek, F. Schäfer, C. Herbivo, M. Goeldner, A. Specht, J. Wachtveitl, A. Heckel, Angew Chem Int Ed, 2016, 55(31), 8948−8952.
  • Enhanced gene delivery to the lung using biodegradable polyunsaturated cationic phosphatidylcholine-detergent conjugates. P. Pierrat, D. Kereselidze, M. Lux, L. Lebeau, F. Pons, Int J Pharm 2016, 511:205-218.
  • DOPC-Detergent conjugates: Fusogenic carriers for improved in vitro and in vivo gene delivery. P. Pierrat, A. Casset, D. Kereselidze,  M. Lux, F. Pons, L. Lebeau Macromol Biosci 2016, 7:984-989.
  • Cationic DOPC-detergent conjugates for safe and efficient in vitro and in vivo nucleic acid delivery. P. Pierrat, A. Casset, P. Didier, D. Kereselidze, M. Lux, F. Pons, L. Lebeau, Chembiochem 2016, 17:1771-1783.
  • Liposomal constructs for antitumoral vaccination by the nasal route. Z. Kakhi,  B. Frisch, B. Heurtault, F. Pons,  Biochimie 2016, 130:14-22.
  • How in vitro assays contribute to allergy diagnosis. A. Casset, N. Khayath, F. de Blay, Curr Allergy Asthma Rep 2016, 16:82.

2015

  • Conformational Change of Self-Assembled DNA Nanotubes Induced by Two-Photon Excitation, Z. Dai, D. Y. Tam, H. Xu, M. S. Chan, L. S. Liu, F. Bolze, X. H. Sun, P. K. Lo, Small, 2015, 11 (33), 4090-4096.
  • Indole-based Cyanine as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging, L. Guo, M. S. Chan, D. Xu, D. Y. Tam, F. Bolze, P. K. Lo, M. S.  Wong, ACS chemical biology, 2015, 10 (5), 1171-1175.
  • Synthesis and Characterization of Carbazole-Linked Porphyrin Tweezers, Y. Chang, C. Michelin, L. Bucher, N. Desbois, C. P. Gros, S. Piant, F. Bolze, Y. Fang, X. Jiang, K. M. Kadish, Chemistry – A European Journal2015, 21 (34), 12018-12025.
  • Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy, J. Schmitt, V. Heitz, A. Sour, F. Bolze, H. Ftouni, J.-F. Nicoud, L. Flamigni, B. Ventura, Angew Chem Int Ed Engl, 2015, 54 (1), 169-173.
  • Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. P. Pierrat, R. Wang, D. Kereselidze, M. Lux, P. Didier, A. Kichler, F. Pons, L. Lebeau, Biomaterials 2015, 51:290-302.
  • Characterization of titratable amphiphiles in lipid membranes by fluorescence spectroscopy. P. Pierrat, L. Lebeau, Langmuir 2015, 31:12362-12371.
  • Airway administration of a highly versatile peptide-based liposomal construct for local and distant antitumoral vaccination. Z. Kakhi, B. Frisch, L. Bourel-Bonnet, J. Hemmerle, F. Pons, B. Heurtault, Int J Pharm 2015, 496:1047-1056.
  • Synthesis of monodisperse sequence-coded polymers with chain lengths above DP100. A. Al Ouahabi, M. Kotera, L. Charles, J-F. Lutz, ACS Macro Lett 2015, 4:1077-1080.

2014

  • A Polyurethane-Based Positive Photoresist,, L. Garcia-Fernández, A. Specht, A. del Campo, Macromol. Rapid Commun, 2014, 35(20):1801-1807.
  • Dual Photosensitive Polymers with Wavelength-Selective Photoresponse, L. Garcia-Fernández, C. Herbivo, V. San Miguel Arranz, D. Warther, L. Donato, A. Specht, A. del Campo, Advanced Materials, 2014, 26, 5012–5017.
  • Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma, C. Ronzani, A. Casset, F. Pons, Arch Toxicol 2014, 88: 489-499.
  • Asthma management and inhalation techniques among community pharmacists in 2009: A comparison with the 1999 survey, A. Casset, M. Meunier-Spitz, P. Rebotier, H. Lefevre, C. Barth, C. Heitz, F. de Blay, J Asthma 2014, 51: 964-973.