Biographie courte
Thomas Grutter est directeur de recherche (DR1) au CNRS (section 25 du CoNRS) et directeur de l’UMR 7199 CBST depuis janvier 2024. Il a été directeur adjoint de l’UMR 7199 CAMB de 2017 à 2023.
Après avoir étudié la chimie et la biologie à l’université Louis Pasteur de Strasbourg dans les années 90 (double diplôme du Magistère Chimie-Biologie et d’un DEA en Pharmacochimie), Thomas a obtenu un doctorat en chimie bioorganique sous la direction du professeur Maurice Goeldner en 2000. Il s’est ensuite orienté pendant son stage postdoctoral vers l’étude structure-fonction de récepteurs canaux impliqués dans la communication neuronale, dans le laboratoire du professeur Jean-Pierre Changeux à l’Institut Pasteur à Paris. Il a rejoint le CNRS en 2003 dans ce même laboratoire et a obtenu son habilitation à diriger des recherches (HDR) en 2007.
La même année, Thomas Grutter retourne à Strasbourg pour créer sa propre équipe de recherche à la Faculté de Pharmacie à Illkirch, dont la thématique est centrée sur les aspects biophysiques et moléculaires des canaux ioniques et des récepteurs canaux (récepteurs P2X et canaux Piezo) en utilisant les outils de la chémobiologie. Il a formé depuis plus d’une dizaine de doctorants et postdoctorants et ses publications comprennent notamment son travail pionnier sur le développement des premiers récepteurs P2X activés par la lumière, publié dans PNAS en 2013, et plus récemment sur les canaux Piezo, publié dans Nature Communications en 2023, ainsi que sur les aspects biophysiques du mécanisme d’ouverture et de perméation ionique des récepteurs P2X (PNAS 2011 ; EMBO J. 2012, eLife 2016 ; PNAS 2017). Thomas Grutter a reçu le Prix La Recherche en 2014, et est devenu USIAS Fellow en 2019.
Publications Unistra
56 publications disponibles
Articles scientifiques
- Microglial P2X4 receptors are essential for spinal neurons hyperexcitability and tactile allodynia in male and female neuropathic mice, iScience | 2023
Co-auteur(s) : Damien Gilabert - Alexia Duveau - Sara Carracedo - Nathalie Linck - Adeline Langla - Rieko Muramatsu - Friedrich Koch-Nolte - François Rassendren - Pascal Fossat - Eric Boué-Grabot - Lauriane Ulmann - Optical control of PIEZO1 channels, Nature Communications | 2023
Co-auteur(s) : Francisco Andrés Peralta - Melaine Balcon - Adeline Martz - Deniza Biljali - Federico Cevoli - Benoit Arnould - Antoine Taly - Thierry Chataigneau - Untangling Macropore Formation and Current Facilitation in P2X7, International Journal of Molecular Sciences | 2023
Co-auteur(s) : Federico Cevoli - Benoit Arnould - Francisco Andrés Peralta - Comparing transmembrane protein structures with ATOLL, Bioinformatics | 2021
Co-auteur(s) : Célien Jacquemard - Guillaume Bret - Esther Kellenberger - P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation, International Journal of Molecular Sciences | 2021
Co-auteur(s) : Kate Dunning - Adeline Martz - Francisco Andés Peralta - Federico Cevoli - Eric Boué-Grabot - Vincent Compan - Fanny Gautherat - Patrick Wolf - Thierry Chataigneau - Photo-isomerizable tweezers to probe ionotropic receptor mechanisms, Current Opinion in Pharmacology | 2021
Co-auteur(s) : Laurie Peverini - Kate Dunning - Francisco Andres Peralta - Update of P2X receptor properties and their pharmacology: IUPHAR Review 30, British Journal of Pharmacology | 2021
Co-auteur(s) : Peter Illes - Christa E. Müller - Kenneth A. Jacobson - Annette Nicke - Samuel J. Fountain - Charles Kennedy - Günther Schmalzing - Michael F. Jarvis - Stanko S. Stojilkovic - Brian F. King - Francesco Di Virgilio - P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling, eneuro | 2020
Co-auteur(s) : Matthias Ollivier - Juline Beudez - Nathalie Linck - Vincent Compan - Francois Rassendren - Molecular determinants for agonist recognition and discrimination in P2X2 receptors, Journal of General Physiology | 2019
Co-auteur(s) : Federica Gasparri - Jesper Wengel - Stephan A. Pless - New Insights Into Permeation of Large Cations Through ATP-Gated P2X Receptors, Frontiers in Molecular Neuroscience | 2018
Co-auteur(s) : Laurie Peverini - Juline Beudez - Kate Dunning - Thierry Chataigneau - On the permeation of large organic cations through the pore of ATP-gated P2X receptors, Proceedings of the National Academy of Sciences | 2017
Co-auteur(s) : Mahboubi Harkat - Laurie Peverini - Adrien H. Cerdan - Kate Dunning - Juline Beudez - Adeline Martz - Nicolas Calimet - Alexandre Specht - Marco Cecchini - Thierry Chataigneau - P2X2 Dominant Deafness Mutations Have No Negative Effect on Wild-Type Isoform: Implications for Functional Rescue and in Deafness Mechanism, Frontiers in Molecular Neuroscience | 2017
Co-auteur(s) : Yan Zhu - Juline Beudez - Ning Yu - Hong-Bo Zhao - Molecular structure and function of P2X receptors, Neuropharmacology | 2016
Co-auteur(s) : Chloé Habermacher - Kate Dunning - Thierry Chataigneau - Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel, eLife | 2016
Co-auteur(s) : Chloé Habermacher - Adeline Martz - Nicolas Calimet - Damien Lemoine - Laurie Peverini - Alexandre Specht - Marco Cecchini - Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels, Journal of Molecular Biology | 2015
Co-auteur(s) : Stephan Kellenberger - Exploring the ATP-binding site of P2X receptors, Frontiers in Cellular Neuroscience | 2013
Co-auteur(s) : Thierry Chataigneau - Damien Lemoine - Moving through the gate in ATP-activated P2X receptors, Trends in Biochemical Sciences | 2013
Co-auteur(s) : Ruotian Jiang - Antoine Taly - Optical control of an ion channel gate, Proceedings of the National Academy of Sciences of the United States of America | 2013
Co-auteur(s) : Damien Lemoine - Chloe Habermacher - Adeline Martz - Pierre-Francois Mery - Nathalie Bouquier - Fanny Diverchy - Antoine Taly - Francois Rassendren - Alexandre Specht - Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor, Channels | 2012
Co-auteur(s) : Ruotian Jiang - Antoine Taly - Damien Lemoine - Adeline Martz - Alexandre Specht - Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor, Proceedings of the National Academy of Sciences of the United States of America | 2012
Co-auteur(s) : Eva Loerinczi - Yogesh Bhargava - Stephen Marino - Antoine Taly - Karina Kaczmarek-Hajek - Alonso Barrantes-Freer - Sebastien Dutertre - Juergen Rettinger - Annette Nicke - Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition, Chemical Reviews | 2012
Co-auteur(s) : Damien Lemoine - Ruotian Jiang - Antoine Taly - Thierry Chataigneau - Alexandre Specht - Tightening of the ATP-binding sites induces the opening of P2X receptor channels, EMBO Journal | 2012
Co-auteur(s) : Ruotian Jiang - Antoine Taly - Damien Lemoine - Adeline Martz - Olivier Cunrath - Agonist trapped in ATP-binding sites of the P2X2 receptor, Proceedings of the National Academy of Sciences of the United States of America | 2011
Co-auteur(s) : Ruotian Jiang - Damien Lemoine - Adeline Martz - Antoine Taly - Sophie Gonin - Lia de Carvalho - Alexandre Specht - From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules, Toxins | 2011
Co-auteur(s) : Adak Nasiripourdori - Valerie Taly - Antoine Taly - Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA(A) receptors in vitro, British Journal of Pharmacology | 2011
Co-auteur(s) : Ruotian Jiang - Akiko Miyamoto - Adeline Martz - Alexandre Specht - Hitoshi Ishibashi - Marie Kueny-Stotz - Stefan Chassaing - Raymond Brouillard - Lia de Carvalho - Maurice Goeldner - Junichi Nabekura - Mogens Nielsen - A Putative Extracellular Salt Bridge at the Subunit Interface Contributes to the Ion Channel Function of the ATP-gated P2X2 Receptor, Journal of Biological Chemistry | 2010
Co-auteur(s) : Ruotian Jiang - Adeline Martz - Sophie Gonin - Antoine Taly - Lia Prado De Carvalho - Comparative models of P2X2 receptor support inter-subunit ATP-binding sites, Biochemical and Biophysical Research Communications | 2008
Co-auteur(s) : Guillaume Guerlet - Antoine Taly - Lia Prado De Carvalho - Adeline Martz - Ruotian Jiang - Alexandre Specht - Nicolas Le Novère - A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family, Nature | 2007
Co-auteur(s) : Nicolas Bocquet - Lia Prado De Carvalho - Jean Cartaud - Jacques Neyton - Chantal Le Poupon - Antoine Taly - Jean-Pierre Changeux - Pierre-Jean Corringer - Dynamic Structural Investigations on the Torpedo Nicotinic Acetylcholine Receptor by Time‐Resolved Photoaffinity Labeling, ChemBioChem | 2006
Co-auteur(s) : Alexandre Mourot - Maurice Goeldner - Florence Kotzyba‐Hibert - Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors, Proceedings of the National Academy of Sciences | 2006
Co-auteur(s) : Antoine Taly - Pierre-Jean Corringer - Lia Prado De Carvalho - Martin Karplus - Jean-Pierre Changeux - A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels, Comptes Rendus. Biologies | 2005
Co-auteur(s) : Lia Prado De Carvalho - Virginie Dufresne - Antoine Taly - Markus Fischer - Jean-Pierre Changeux - Molecular tuning of fast gating in pentameric ligand-gated ion channels, Proceedings of the National Academy of Sciences | 2005
Co-auteur(s) : Lia Prado De Carvalho - Virginie Dufresne - Antoine Taly - Stuart J. Edelstein - Jean-Pierre Changeux - Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism, Biophysical Journal | 2005
Co-auteur(s) : Antoine Taly - Marc Delarue - Michael Nilges - Nicolas Le Novère - Pierre-Jean Corringer - Jean-Pierre Changeux - Rational understanding of nicotinic receptors drug binding, Current Topics in Medicinal Chemistry | 2004
Co-auteur(s) : Nicolas Le Novere - Jean-Pierre Changeux - An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors, The EMBO Journal | 2003
Co-auteur(s) : Lia Prado De Carvalho - Nicolas Le Novère - Pierre-Jean Corringer - Stuart Edelstein - Jean-Pierre Changeux - Syntheses and biological properties of cysteine-Reactive epibatidine derivatives, Bioorganic and Medicinal Chemistry Letters | 2003
Co-auteur(s) : Christian Che - Grégory Petit - Florence Kotzyba-Hibert - Sonia Bertrand - Daniel Bertrand - Maurice Goeldner - Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca 2+ -binding sites, Proceedings of the National Academy of Sciences | 2002
Co-auteur(s) : Nicolas Le Novère - Jean-Pierre Changeux - Structural Reorganization of the Acetylcholine Binding Site of the Torpedo Nicotinic Receptor as Revealed by Dynamic Photoaffinity Labeling, ChemBioChem | 2002
Co-auteur(s) : Sonia Bertrand - Florence Kotzyba-Hibert - Daniel Bertrand - Maurice Goeldner - Cysteine mutants as chemical sensors for ligand–receptor interactions, Trends in Pharmacological Sciences | 2001
Co-auteur(s) : Bernard Foucaud - Philippe Perret - Maurice Goeldner - Nicotinic receptors in wonderland, Trends in Biochemical Sciences | 2001
Co-auteur(s) : Jean-Pierre Changeux - Photoaffinity Labeling of Torpedo Nicotinic Receptor with the Agonist [ 3 H]DCTA: Identification of Amino Acid Residues Which Contribute to the Binding of the Ester Moiety of Acetylcholine, Biochemistry | 2000
Co-auteur(s) : Laurence Ehret-Sabatier - Florence Kotzyba-Hibert - Maurice Goeldner - Molecular investigations on the nicotinic acetylcholine receptor, Molecular Neurobiology | 1999
Co-auteur(s) : Florence Kotzyba-Hibert - Maurice Goeldner - Nicotinic Acetylcholine Receptor Probed with a Photoactivatable Agonist: Improved Labeling Specificity by Addition of Ce IV /Glutathione. Extension to Laser Flash Photolabeling, Biochemistry | 1999
Co-auteur(s) : Maurice Goeldner - Florence Kotzyba-Hibert - Nicotinic Acetylcholine Receptor Labeled with a Tritiated, Photoactivatable Agonist: A New Tool for Investigating the Functional, Activated State, Bioconjugate Chemistry | 1997
Co-auteur(s) : Florence Kotzyba-Hibert - Pascal Kessler - Vincent Zerbib - Christian Bogen - Kenneth Takeda - Akli Hammadi - Laurent Knerr - Maurice Goeldner
Conférences
- New insights into P2X permeation | 2021
- Les cibles thérapeutiques de demain : de la structure moléculaire à la fonction | 2019
- Molecular engineering of ATP-gated P2X ion channels provides new insights into ion permeation and gating mechanisms | 2019
- Optical control of P2X receptors | 2019
- Permeation mechanisms of large cations in ATP-gated P2X ion channels | 2019
- Optical control of P2X receptors | 2018
- Opening of a P2X ion channel with light, Purinergic Signalling | 2014
- Optical dissection of gating in P2X receptors, Purinergic Signalling | 2014
Co-auteur(s) : Chloe Habermacher - Damien Lemoine - Adeline Martz - Alexandre Specht - Optogating a powerful approach to control an ion-channel gate, Purinergic Signalling | 2014
Co-auteur(s) : Damien Lemoine - Chloe Habermacher - Adeline Martz - Pierre-Francois Mery - Nathalie Bouquier - Fanny Diverchy - Antoine Taly - Francois Rassendren - Alexandre Specht
Parties d'ouvrages
- Manipulation of ion channel gating with photoswitchable tweezers., Methods in enzymology | 2021
Co-auteur(s) : Kate Dunning - P2X Receptors, Neuronal Ion Channels | 2018
Co-auteur(s) : Annette Nicke - Terrance Egan
Productions de vulgarisation
- Des nanomachines photochimiques pour explorer le vivant | 2017
Co-auteur(s) : Chloé Habermacher - Laurie Peverini